Imazalil
English name: imazalil CAS:35554-44-0 Molecular formula: C14H14Cl2N2O
Classification:
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Tags：APIRaw materialsFungicide
Detailed introduction
Production method
Preparation of 1.2 ',2,4-trichloroacetophenone After 14.7g of m-dichlorobenzene was mixed with 16.7g of anhydrous aluminum trichloride, 12.6g of chloroacetyl chloride was added dropwise with stirring. The reaction was completed for 3h, hydrolyzed, filtered, washed with water and dried to obtain the crude product, which was recrystallized from ethanol with a yield of 83.7.
2. Preparation of 1-chloromethyl-2, 4-dichlorobenzyl methanol 66.7g of the product of the previous step was mixed with anhydrous methanol and stirred to dissolve. Under ice-water bath cooling, sodium borohydride was added in batches, the reaction was continued for 5min after addition, 30mL of water was added, and then stirred for 10min. Evaporation of methanol, dilute hydrochloric acid neutralization, filtration, drying product 6.3g, yield 93%.
3. Preparation of 1-[2-(2,4-dichlorophenyl)-2-hydroxyethyl]-1H-imidazole After mixing 1.0g of the 2-step product, 0.3g of imidazole, 0.2g of organic amine, 0.2g of powdered sodium hydroxide and 5.5mL of organic solvent, the reaction was stirred at 70 ℃ for 4 hours, cooled, 30mL of water was added, filtered and dried to obtain 1g of solid product with a yield of 87%.
4. Synthesis of Imazalil 0.5g of the 3-step product, 0.24g of chloropropene, 0.1g of powdered sodium hydroxide, 0.1g of organic amine and 5mL of organic solvent were stirred for reaction for 24g, water and ether were added for extraction, washed with water until neutral, dried and dissolved to obtain 0.5g of liquid with a yield of 86.5.
Use
A new type of fungicide and seed treatment agent for fruits.
In the future, Jingzhou Ruidong Pharmaceutical Technology Co., Ltd. will continue to cultivate the field of imidazole antifungal raw materials, and continue to expand the scope of business. The company's research and development projects will mainly focus on antifungal and other series of biological drugs, animal medicine, blood esters and other three major areas. At the same time, the company will also pay close attention to market demand and expand the production of various types of APIs urgently needed by the market to meet the needs of various customers in the current and future pharmaceutical industry.
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